• 復(fù)旦大學(xué)附屬中山醫(yī)院、肝癌研究所（上海 200032）;

引用本文： 葉青海. 肝癌分子分型和轉(zhuǎn)移復(fù)發(fā)的早期預(yù)測(cè). 中國普外基礎(chǔ)與臨床雜志, 2007, 14(1): 8-10. doi: 復(fù)制

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1. 　Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [J]. CA Cancer J Clin， 2005; 55(2)∶74.
2. 　Tang ZY, Ye SL, Liu YK, et al. A decade’s studies on metastasis of hepatocellular carcinoma [J]. J Cancer Res Clin Oncol， 2004; 130(4)∶187.
3. 　Mitsunobu M, Toyosaka A, Oriyama T, et al. Intrahepatic metastases in hepatocellular carcinoma: the role of the portal vein as an efferent vessel [J]. Clin Exp Metastasis， 1996; 14(6)∶520.
4. 　Liotta L, Petricoin E. Molecular profiling of human cancer [J]. Nat Rev Genet， 2000; 1(1)∶48.
5. 　Elston CW, Sloane JP, Amendoeira I, et al. Causes of inconsistency in diagnosing and classifying intraductal proliferations of the breast. European Commission Working Group on Breast Screening Pathology [J]. Eur J Cancer， 2000; 36(14)∶1769.
6. 　TungPing Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma [J]. Ann Surg， 2000; 232(1)∶10.
7. 　Kobayashi T, Kubota K, Takayama T, et al. Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy [J]. Am J Surg， 2001; 181(3)∶284.
8. 　Ijichi M, Takayama T, Matsumura M, et al. alphaFetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: a prospective study [J]. Hepatology， 2002; 35(4)∶853.
9. 　Huang GT, Lee HS, Chen CH, et al. Correlation of Ecadherin expression and recurrence of hepatocellular carcinoma [J]. Hepatogastroenterology， 1999; 46(27)∶1923.
10. 　Schena M, Shalon D, Davis RW, et al. Quantitative monitoring of gene expression patterns with a complementary DNA microarray [J]. Science， 1995; 270(5235)∶467.
11. 　DeRisi J, Penland L, Brown PO, et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer [J]. Nat Genet， 1996; 14(4)∶457.
12. 　Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring [J]. Science， 1999; 286(5439)∶531.
13. 　Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large Bcell lymphoma identified by gene expression profiling [J]. Nature， 2000; 403(6769)∶503.
14. 　Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours [J]. Nature， 2000; 406(6797)∶747.
15. 　van’t Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer [J]. Nature， 2002; 415(6871)∶530.
16. 　Weigelt B, Glas AM, Wessels LF, et al. Gene expression profiles of primary breast tumors maintained in distant metastases [J]. Proc Natl Acad Sci USA， 2003; 100(26)∶15901.
17. 　Ramaswamy S, Ross KN, Lander ES, et al. A molecular signature of metastasis in primary solid tumors [J]. Nat Genet， 2003; 33(1)∶49.
18. 　Onken MD, Ehlers JP, Worley LA, et al. Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas [J]. Cancer Res， 2006; 66(9)∶4602.
19. 　Carrasco DR, Tonon G, Huang Y, et al. Highresolution genomic profiles define distinct clinicopathogenetic subgroups of multiple myeloma patients [J]. Cancer Cell， 2006; 9(4)∶313.
20. 　Ye QH, Qin LX, Forgues M, et al. Predicting hepatitis B viruspositive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning [J]. Nat Med， 2003; 9(4)∶416.
21. 　Iizuka N, Oka M, YamadaOkabe H, et al. Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection [J]. Lancet， 2003; 361(9361)∶923.
  1. 1. 　Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002 [J]. CA Cancer J Clin， 2005; 55(2)∶74.
  2. 2. 　Tang ZY, Ye SL, Liu YK, et al. A decade’s studies on metastasis of hepatocellular carcinoma [J]. J Cancer Res Clin Oncol， 2004; 130(4)∶187.
  3. 3. 　Mitsunobu M, Toyosaka A, Oriyama T, et al. Intrahepatic metastases in hepatocellular carcinoma: the role of the portal vein as an efferent vessel [J]. Clin Exp Metastasis， 1996; 14(6)∶520.
  4. 4. 　Liotta L, Petricoin E. Molecular profiling of human cancer [J]. Nat Rev Genet， 2000; 1(1)∶48.
  5. 5. 　Elston CW, Sloane JP, Amendoeira I, et al. Causes of inconsistency in diagnosing and classifying intraductal proliferations of the breast. European Commission Working Group on Breast Screening Pathology [J]. Eur J Cancer， 2000; 36(14)∶1769.
  6. 6. 　TungPing Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma [J]. Ann Surg， 2000; 232(1)∶10.
  7. 7. 　Kobayashi T, Kubota K, Takayama T, et al. Telomerase activity as a predictive marker for recurrence of hepatocellular carcinoma after hepatectomy [J]. Am J Surg， 2001; 181(3)∶284.
  8. 8. 　Ijichi M, Takayama T, Matsumura M, et al. alphaFetoprotein mRNA in the circulation as a predictor of postsurgical recurrence of hepatocellular carcinoma: a prospective study [J]. Hepatology， 2002; 35(4)∶853.
  9. 9. 　Huang GT, Lee HS, Chen CH, et al. Correlation of Ecadherin expression and recurrence of hepatocellular carcinoma [J]. Hepatogastroenterology， 1999; 46(27)∶1923.
  10. 10. 　Schena M, Shalon D, Davis RW, et al. Quantitative monitoring of gene expression patterns with a complementary DNA microarray [J]. Science， 1995; 270(5235)∶467.
  11. 11. 　DeRisi J, Penland L, Brown PO, et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer [J]. Nat Genet， 1996; 14(4)∶457.
  12. 12. 　Golub TR, Slonim DK, Tamayo P, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring [J]. Science， 1999; 286(5439)∶531.
  13. 13. 　Alizadeh AA, Eisen MB, Davis RE, et al. Distinct types of diffuse large Bcell lymphoma identified by gene expression profiling [J]. Nature， 2000; 403(6769)∶503.
  14. 14. 　Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours [J]. Nature， 2000; 406(6797)∶747.
  15. 15. 　van’t Veer LJ, Dai H, van de Vijver MJ, et al. Gene expression profiling predicts clinical outcome of breast cancer [J]. Nature， 2002; 415(6871)∶530.
  16. 16. 　Weigelt B, Glas AM, Wessels LF, et al. Gene expression profiles of primary breast tumors maintained in distant metastases [J]. Proc Natl Acad Sci USA， 2003; 100(26)∶15901.
  17. 17. 　Ramaswamy S, Ross KN, Lander ES, et al. A molecular signature of metastasis in primary solid tumors [J]. Nat Genet， 2003; 33(1)∶49.
  18. 18. 　Onken MD, Ehlers JP, Worley LA, et al. Functional gene expression analysis uncovers phenotypic switch in aggressive uveal melanomas [J]. Cancer Res， 2006; 66(9)∶4602.
  19. 19. 　Carrasco DR, Tonon G, Huang Y, et al. Highresolution genomic profiles define distinct clinicopathogenetic subgroups of multiple myeloma patients [J]. Cancer Cell， 2006; 9(4)∶313.
  20. 20. 　Ye QH, Qin LX, Forgues M, et al. Predicting hepatitis B viruspositive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning [J]. Nat Med， 2003; 9(4)∶416.
  21. 21. 　Iizuka N, Oka M, YamadaOkabe H, et al. Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection [J]. Lancet， 2003; 361(9361)∶923.