• 1. 成都軍區(qū)總醫(yī)院全軍腹部外科中心(成都610083)2. 第三軍醫(yī)大學新橋醫(yī)院普通外科;

為研究胃大部切除術后殘胃粘膜屏障損傷與殘胃粘膜癌前病變的關系，在甲基硝基亞硝基胍(N-methy-N’-nitro-Nnitrosoguanidine,MNNG)誘發(fā)犬殘胃粘膜癌前病變過程中，胃鏡下定期行殘胃粘膜活檢的同時，對跨胃粘膜電位差(gastric transmucosal potential difference, GTPD)及粘膜細胞核DNA含量進行了動態(tài)測定。結果：隨著殘胃吻合口粘膜病變加重，GTPD值呈漸進性下降趨勢，且GTPD值與相應粘膜細胞核DNA含量之間呈顯著負相關關系。本實驗結果提示：隨著殘胃粘膜屏障損傷程度的加重，粘膜組織細胞惡變潛能就越大；殘胃粘膜屏障損傷在殘胃癌前病變發(fā)生過程中起著至關重要的作用。

引用本文： 湯禮軍,田伏洲,麻曉林,周丁華,晏才杰. 殘胃粘膜屏障損傷與殘胃癌前病變關系的實驗研究. 中國普外基礎與臨床雜志, 1999, 6(1): 7-10. doi: 復制

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  1. 1. Takeuchi. Clinical study on gastric mucosal blood flow and potential difference. Gastroenterological Endoscope, 1987; 29(5)∶845.
  2. 2. 全國胃癌防治研究協(xié)作組病理組. 胃及十二指腸粘膜活檢病理. 第1版. 沈陽： 遼寧人民出版社， 1991∶134～135.
  3. 3. Morris CP, Hoei L, Yelson K, et al. Correlation between changes in indicators of gastric mucosal barrier integrity at time of exposure to “barrier breaker” and extent of hemorrhagic erosions one hour later. Dig Dis Sci, 1984; 29(1)∶6.
  4. 4. Goddard PJ, Lenard DM. In vitro recovery of canine gastric mucosal surface hydrophobicity and potential difference after aspirin damage. Dig Dis Sci, 1995; 40(6)∶1357.
  5. 5. Sorbye H, Pieol HY, Scot LE, et al. Gastric carcinogenesis in rats given hypertonic salt at different times before a single dose of MNNG. J Cancer Res Clin Oncol, 1994; 120(120)∶159.
  6. 6. Hiraki Y. Experimental study of the effect of bile juice on the remnant gastric cancer development. Hippon Geka Gakkai Zasshi, 1991; 92(6)∶645.
  7. 7. 湯禮軍， 晏才杰， 麻曉林等. MNNG誘發(fā)犬殘胃粘膜癌前病變組織中MG7Ag表達的動態(tài)定量研究. 胃腸病學和肝病學雜志， 1996； 5(1)∶32.
  8. 8. Imai T, Moit L, Soue H,et al. Reduction of cell proliferative activities of gastric stump adenomatous hyperplasias after bile reflux diversion in rats. Carcinogenesis, 1993; 14(23)∶1765.
  9. 9. Tanigawa N, Masuda Y, Shimo T, et al. Thymidine uptake in vitro as a prognostic indicator for primary gastric cancer. Cancer, 1993; 72(10)∶2883.
  10. 10. Fisher SG, Davis F, Nelson R, et al. A cohort study of stomach cancer risk in men after gastric surgery for benign disease. J Natl Cancer Inst, 1993; 85(16)∶1303.