• 西安醫(yī)科大學附屬第一醫(yī)院普通外科(西安710061);

為探討CA50在結直腸癌的診斷和術后監(jiān)測方面的臨床應用價值,應用免疫放射測定法(IRMA)對30例健康人、66例結直腸癌及27例結直腸良性病患者血清CA50水平進行了檢測。結果:結直腸惡性腫瘤患者血清CA50值顯著高于良性病患者及健康人(P<0.01);結直腸癌行根治手術后其血清CA50含量較術前明顯降低(P<0.01),術后復發(fā)者又再升高,而行姑息手術后其變化不顯著(P>0.05)。提示檢測血清CA50含量在結直腸癌的診斷和術后隨訪監(jiān)測中具有一定的臨床實用價值。

引用本文: 王康,劉浩,許延發(fā). 監(jiān)測結直腸癌患者血清糖鏈抗原CA50的臨床意義. 中國普外基礎與臨床雜志, 1999, 6(1): 24-25. doi: 復制

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  2. 2. Holmgren J,Lindholm L, Pesson B, et al. Detection by monoclinal antibody of carbohydrate antigen CA50 in serum of patients with carcinoma. Br Med J, 1984; 288(19)∶1479.
  3. 3. Hershman MJ, Habib NA, Ferro MA, et al. The use of CA50 radioimmunassay test in diagnosis of urologic malignancy.Am Surgeon, 1987; 53(9)∶691.
  4. 4. 張登學, 張翠萍, 徐向嵐等. 血清糖鏈抗原50對胃癌的診斷價值. 腫瘤防治研究, 1995; 22(4)∶224.
  5. 5. 李長嶺, 許秉責, 陳智周等. 腫瘤相關抗原CA50監(jiān)測泌尿男生殖系統(tǒng)惡性腫瘤的臨床意義. 中華腫瘤雜志, 1994; 16(2)∶148.
  6. 6. 王穎, 葉秀, 徐冰等. 血清CA50含量對消化系統(tǒng)腫瘤的診斷價值. 新消化病學雜志, 1997; 5(8)∶514.
  7. 7. 張登學, 牟永善, 郭英華等. 惡性腫瘤患者血清糖鏈抗原50的變化及其臨床意義. 中華內科雜志, 1992; 31(12)∶766.