為探討梗阻性黃疸患者敗血癥的發(fā)生機理，研究了37例梗阻性黃疸（A組）和90例膽囊結石（B組）患者的膽道內(nèi)壓力、門靜脈血流速度與白細胞介素-2（IL-2）、可溶性白細胞介素-2受體（sIL-2R）及T淋巴細胞亞群的關系。A組又分為急診手術組（A1）、擇期手術組（A2）、 gt;60歲組（A3）和 lt;60歲組（A4）4個亞組。結果顯示：A及A1~4各組術前CD3+、CD4+、CD8+值均顯著低于術后10天值（P lt;0.05或P lt;0.01），sIL-2R顯著高于術后10天值（P lt;0.01）。A1組術前sIL-2R極顯著高于A及A2~4組（P lt;0.01）。相關分析顯示膽道內(nèi)壓力與IL-2、CD3+、CD4+、及CD8+呈負相關，與sIL-2R呈正相關（P lt;0.01），門靜脈血流速度與IL-2呈正相關（P lt;0.01）。由此表明梗阻性黃疸感染與宿主細胞免疫功能降低密切相關。
引用本文： 方馳華,戴永貴,鄧明福,趙慧仁,周玉寶. 梗阻性黃疸時膽道內(nèi)壓力和門靜脈血流與IL-2、sIL-2R及T淋巴細胞亞群變化的關系探討. 中國普外基礎與臨床雜志, 1996, 3(4): 196-199. doi: 復制
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- 2. Greve JW,Gouma DJ,Soeters PB,et al.Suppression of cellular immunity in obstructive jaundice is caused by endotoxins.Gastroenterology,1990;98(2):478.
- 3. Mathie RT,Nagorney DM,Lewis MH,et al.Hepatic hemodynamics after chronic obstruction of biliary tract in the dog.Surg Gyn Obstet,1988;166(2):125.
- 4. Roughneen PT,Gouma DJ,Kulkarni AD,et al.Imparied sepecific cell-mediated immunity in experimental biliary obstruction and its reversibility by internal biliary drainage.J Res Surg,1986;41(2):113.