目的 研究前白蛋白( PA) 、D-二聚體( DD) 及Plt 動態(tài)變化與重癥膿毒癥患者病情嚴重度及預后的關系。方法 測定198 例重癥膿毒癥患者入組第1 d、第5 d, 以及出院或死亡前最后一次的PA、DD、Plt、APACHEⅡ 評分, 按預后將患者分為死亡組及存活組, 進行動態(tài)觀察, 并做APACHEⅡ評分和PA、DD 及PLT 水平動態(tài)變化的相關性分析。結果 死亡組與存活組入組第1 dPA、DD 及Plt 比較均無顯著差異, 死亡組第5 d 及最后一次DD 水平明顯高于存活組( P lt;0. 05) , PA和Plt 明顯低于存活組( P lt;0. 01) 。DD 與APACHEⅡ評分呈正相關, PA、Plt 與APACHEⅡ評分呈負相關。結論 DD與膿毒癥患者病情嚴重程度呈正相關, PA 與病情嚴重程度呈負相關。DD 持續(xù)高水平與PA、Plt 持續(xù)低水平提示病情危重, 預后不良, 所以聯(lián)合動態(tài)觀察PA、DD 和Plt 對判斷病情危重度及預后有一定的評估價值。
引用本文： 楊鈞,奚晶晶. 前白蛋白、D-二聚體及血小板動態(tài)變化評估重癥膿毒癥患者病情嚴重度的臨床分析. 中國呼吸與危重監(jiān)護雜志, 2009, 09(3): 292-293. doi: 復制
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