• 1. 深圳市中醫(yī)院,深圳,5180332. 四川大學(xué)華西醫(yī)院中國(guó)循證醫(yī)學(xué)中心/國(guó)際臨床流行病學(xué)網(wǎng)華西研究與培訓(xùn)中心,成都,610041;

目的 　評(píng)價(jià)茵梔黃注射液對(duì)黃疸型病毒性肝炎的退黃效果與安全性.
方法 　計(jì)算機(jī)檢索MEDLINE(1966～2005),Cochrane 圖書館(2005年第1期)的臨床對(duì)照試驗(yàn)資料庫(kù)、肝病組資料庫(kù),中國(guó)生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫(kù)(1978～2004),中文生物醫(yī)學(xué)期刊文獻(xiàn)數(shù)據(jù)庫(kù)(1994～2005),中國(guó)醫(yī)學(xué)學(xué)術(shù)會(huì)議論文數(shù)據(jù)庫(kù)(1994～2005),中國(guó)期刊全文數(shù)據(jù)庫(kù)(1994～2005),中文科技期刊數(shù)據(jù)庫(kù)(1989～2004).納入茵梔黃注射液治療黃疸型病毒性肝炎的隨機(jī)對(duì)照試驗(yàn)及半隨機(jī)對(duì)照試驗(yàn),并對(duì)其進(jìn)行質(zhì)量評(píng)價(jià).用RevMan 4.2軟件進(jìn)行統(tǒng)計(jì)分析.
結(jié)果 　共納入4個(gè)隨機(jī)對(duì)照試驗(yàn).Meta分析結(jié)果顯示,對(duì)急性肝炎,單用茵梔黃注射液與西藥陽性對(duì)照藥相比,茵梔黃注射液的退黃效果比西藥對(duì)照藥更優(yōu)或與西藥對(duì)照藥相似[WMD-19.70,95%CI(-32.69,-6.71)和WMD-1.27,95%CI(-3.08,0.54)];但對(duì)慢性肝炎,茵梔黃注射液的退黃作用要弱于思美泰[WMD-106.00,95%CI(-189.05,-22.95)];自身對(duì)照試驗(yàn)結(jié)果顯示,大劑量茵梔黃注射液的退黃作用優(yōu)于小劑量[WMD-11.50,95%CI(-16.53, -6.47)],提示加大用藥劑量,可提高其退黃效率.現(xiàn)有資料未提示有嚴(yán)重不良反應(yīng)發(fā)生.
結(jié)論 　茵梔黃注射液對(duì)黃疸型病毒性肝炎可能有退黃作用,由于納入的研究存在選擇性偏倚、實(shí)施偏倚、測(cè)量性偏倚的高度可能性,尚需更多的高質(zhì)量研究提供可靠的證據(jù)對(duì)其療效及安全性予以證實(shí).

引用本文： 陳 軍,陳輝揚(yáng),劉志承,吳泰相. 茵梔黃注射液對(duì)黃疸型病毒性肝炎的退黃效果與安全性的系統(tǒng)評(píng)價(jià). 中國(guó)循證醫(yī)學(xué)雜志, 2005, 05(6): 461-465. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《中國(guó)循證醫(yī)學(xué)雜志》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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2. 中華醫(yī)學(xué)會(huì)傳染病與寄生蟲病學(xué)分會(huì)、肝病學(xué)分會(huì). 病毒性肝炎防治方案[J]. 中華內(nèi)科雜志, 2001; 40(1): 62.
3. 史天陸, 陶中原, 黃家倫. 茵梔黃注射液的臨床應(yīng)用與展望[J]. 基層中藥志, 2000; 14(3): 58.
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7. 倪若愚, 張佩弦, 羅端德, 阮峻峰. 茵梔黃注射液治療急性黃疸型肝炎的臨床評(píng)價(jià)[J]. 醫(yī)藥導(dǎo)報(bào), 1994; 13(3): 106.
8. 謝仕斌, 黃桂梅, 鄧云珍, 謝冬英, 陳幼明, 姚集魯. 腺苷蛋氨酸治療急、慢性病毒性肝炎的臨床療效[J]. 中國(guó)新藥雜志, 1999; 8(12): 824～826.
9. 屠德敬, 蘭朝廷, 林維進(jìn), 劉盛軍. 茵梔黃注射液治療急性黃疸型肝炎56例療效觀察[J]. 中華實(shí)用中西醫(yī)雜志, 2004; 4(17): 7.
10. 崔建華, 趙春紅, 吳志敏. 茵梔黃注射液治療病毒性肝炎高膽紅素血癥38例療效觀察[J]. 中原醫(yī)刊, 2003; 30(2): 50.
11. 陳海明, 李方學(xué). 茵梔黃對(duì)病毒性肝炎高膽紅素血癥的影響[J]. 浙江中西醫(yī)結(jié)合雜志, 2003; 13(3): 164.
12. Shi LL, Zhang L, Dou XG. Diagnosis of virus hepatitis[J]. Liaoning Medication and Clinic, 2002; 7(2): 64.
13. China Medical Association. Prevention and cure of virus hepatitis[J]. Chinese Journal Intern Medicine, 2001; 40(1): 62.
14. Shi TL, Tao ZY, Huang JL. Clinic applications and expectation of Yinzhihuang Injection[J]. Primary Journal of Chinese Materia Medica, 2000; 14(3): 58.
15. State drug evaluation center. National essentional drugs (Chinese traditional patent medicine)[M]. Beijing: People Medicine Press House, 2003; 417-418.
16. Jin YA, Li YS. Curative effect observation of Yinzhihuang injection for virus hepatitis[J]. Acta Chinese Medicine and Pharmacology, 2002; 30(3): 19.
17. Wang H, Liu J. Effect observation of Yinzhihuang injection for acute icteric hepatitis[J]. Journal of Yunnan College of Traditional Chinese Medicine, 2004; 27(1): 31-32.
18. Ni RY, Zhang PX, Luo DD, Ruan JF. Clinical evaluation on Yinzhihuang injection for acute icteric hepatitis[J]. Herald of Medicine, 1994; 13(3): 106.
19. Aldeson P, Green S, Higgins JPT editors. Cochrane Reviews Handbook 4.2.2[Updated December 2003] [M/CD]. In: The Cochrane Library, Ossue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
20. Xie SB, Huang GM, Deng YZ, Xie DY, Chen YM, Yao JL. Observation of S-Adeanosyl methionine therapeutic effect on acute and chronic hepatitis[J]. Chinese New Drugs Journal, 1999; 8(12): 824-826.
21. Tu DJ, Lan CT, Lin WJ, Liu SJ. Curative effect observation on treating acute icteric hepatitis in 56 cases[J]. Chinese Journal of the Practical Chinese with Modern Medicine, 2004; 4(17): 7.
22. Cui JH, Zhao CH, Wu ZM. Observation of Yinzhihuang Injection for icteric virus hepatitis in 38 cases[J]. Central Plains Medical Journal, 2003; 30(2): 50.
23. Chen HM, Li FX. Effect of Yinzhihuang injection for icteric virus hepatitis[J]. Zhejiang Journal of Chinese with Modern Medicine, 2003; 13(3): 164.
  1. 1. 石理蘭, 張琳, 竇曉光. 病毒性肝炎的診斷[J]. 遼寧藥物與臨床, 2002; 7(2): 64.
  2. 2. 中華醫(yī)學(xué)會(huì)傳染病與寄生蟲病學(xué)分會(huì)、肝病學(xué)分會(huì). 病毒性肝炎防治方案[J]. 中華內(nèi)科雜志, 2001; 40(1): 62.
  3. 3. 史天陸, 陶中原, 黃家倫. 茵梔黃注射液的臨床應(yīng)用與展望[J]. 基層中藥志, 2000; 14(3): 58.
  4. 4. 國(guó)家藥品評(píng)價(jià)中心. 國(guó)家基本藥物(中成藥)[M]. 北京: 人民衛(wèi)生出版社, 2003; 417～418.
  5. 5. 金英愛, 李英順. 茵梔黃注射液治療病毒性肝炎療效觀察[J]. 中醫(yī)藥學(xué)報(bào), 2002; 30(3): 19.
  6. 6. 王輝, 劉俊. 茵梔黃、苦黃、古拉定治療急性黃疸型肝炎療效觀察[J]. 云南中醫(yī)學(xué)院學(xué)報(bào), 2004; 27(1): 31～32.
  7. 7. 倪若愚, 張佩弦, 羅端德, 阮峻峰. 茵梔黃注射液治療急性黃疸型肝炎的臨床評(píng)價(jià)[J]. 醫(yī)藥導(dǎo)報(bào), 1994; 13(3): 106.
  8. 8. 謝仕斌, 黃桂梅, 鄧云珍, 謝冬英, 陳幼明, 姚集魯. 腺苷蛋氨酸治療急、慢性病毒性肝炎的臨床療效[J]. 中國(guó)新藥雜志, 1999; 8(12): 824～826.
  9. 9. 屠德敬, 蘭朝廷, 林維進(jìn), 劉盛軍. 茵梔黃注射液治療急性黃疸型肝炎56例療效觀察[J]. 中華實(shí)用中西醫(yī)雜志, 2004; 4(17): 7.
  10. 10. 崔建華, 趙春紅, 吳志敏. 茵梔黃注射液治療病毒性肝炎高膽紅素血癥38例療效觀察[J]. 中原醫(yī)刊, 2003; 30(2): 50.
  11. 11. 陳海明, 李方學(xué). 茵梔黃對(duì)病毒性肝炎高膽紅素血癥的影響[J]. 浙江中西醫(yī)結(jié)合雜志, 2003; 13(3): 164.
  12. 12. Shi LL, Zhang L, Dou XG. Diagnosis of virus hepatitis[J]. Liaoning Medication and Clinic, 2002; 7(2): 64.
  13. 13. China Medical Association. Prevention and cure of virus hepatitis[J]. Chinese Journal Intern Medicine, 2001; 40(1): 62.
  14. 14. Shi TL, Tao ZY, Huang JL. Clinic applications and expectation of Yinzhihuang Injection[J]. Primary Journal of Chinese Materia Medica, 2000; 14(3): 58.
  15. 15. State drug evaluation center. National essentional drugs (Chinese traditional patent medicine)[M]. Beijing: People Medicine Press House, 2003; 417-418.
  16. 16. Jin YA, Li YS. Curative effect observation of Yinzhihuang injection for virus hepatitis[J]. Acta Chinese Medicine and Pharmacology, 2002; 30(3): 19.
  17. 17. Wang H, Liu J. Effect observation of Yinzhihuang injection for acute icteric hepatitis[J]. Journal of Yunnan College of Traditional Chinese Medicine, 2004; 27(1): 31-32.
  18. 18. Ni RY, Zhang PX, Luo DD, Ruan JF. Clinical evaluation on Yinzhihuang injection for acute icteric hepatitis[J]. Herald of Medicine, 1994; 13(3): 106.
  19. 19. Aldeson P, Green S, Higgins JPT editors. Cochrane Reviews Handbook 4.2.2[Updated December 2003] [M/CD]. In: The Cochrane Library, Ossue 1, 2004. Chichester, UK: John Wiley & Sons, Ltd.
  20. 20. Xie SB, Huang GM, Deng YZ, Xie DY, Chen YM, Yao JL. Observation of S-Adeanosyl methionine therapeutic effect on acute and chronic hepatitis[J]. Chinese New Drugs Journal, 1999; 8(12): 824-826.
  21. 21. Tu DJ, Lan CT, Lin WJ, Liu SJ. Curative effect observation on treating acute icteric hepatitis in 56 cases[J]. Chinese Journal of the Practical Chinese with Modern Medicine, 2004; 4(17): 7.
  22. 22. Cui JH, Zhao CH, Wu ZM. Observation of Yinzhihuang Injection for icteric virus hepatitis in 38 cases[J]. Central Plains Medical Journal, 2003; 30(2): 50.
  23. 23. Chen HM, Li FX. Effect of Yinzhihuang injection for icteric virus hepatitis[J]. Zhejiang Journal of Chinese with Modern Medicine, 2003; 13(3): 164.