• 四川大學(xué)華西醫(yī)院腫瘤中心腹部腫瘤病房,四川成都 610041;

目的:觀察醋酸甲地孕酮(MA)在預(yù)防化療引起的消化道反應(yīng)中的作用。方法:收集2007年6月～2008年6月病理學(xué)和細(xì)胞學(xué)證實(shí)的消化道惡性腫瘤60例,采用自身前后交叉對照研究,隨機(jī)分為AB和BA兩組。AB組第一周期止吐方案用格拉司瓊+胃復(fù)安＋MA,第二周期止吐方案用格拉司瓊+胃復(fù)安;BA組第一周期止吐方案用格拉司瓊+胃復(fù)安,第二周期止吐方案MA＋格拉司瓊+胃復(fù)安。結(jié)果:化療同時配合使用MA惡心、嘔吐發(fā)生率下降(P lt;0.05);惡心、嘔吐程度改善(P.001),并且可以預(yù)防化療引起的急性期和延遲期惡心、嘔吐反應(yīng)(P lt;0.05)。結(jié)論:化療同時配合使用MA可以改善化療患者的惡心嘔吐反應(yīng)

引用本文： 侯敏,臧健,勾紅峰,蔣明,邱萌,畢鋒,易成. 醋酸甲地孕酮預(yù)防化療引起的消化道反應(yīng)的臨床研究. 華西醫(yī)學(xué), 2009, 24(3): 592-594. doi: 復(fù)制

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5. AAPRO MS,GRUNBERG SM,MANIKHAS GM,et al.A phase Ⅲ,doubleblind,randomized trial of palonosetron compared with ondansetron in preventing chemotherapyinduced nausea and vomiting following highly emetogenic chemotherapy[J].Ann Oncol,2006,17(9):1441-1449..
6. GRALLA R,LICHINITSER M,SLEEBOOM H,et al.Palonosetron improves prevention of chemotherapyinduced nausea and vomiting following moderately emetogenic chemotherapy:results of a doubleblind randomized phase Ⅲ trial comparing single doses of palonosetron with ondansetron[J].Ann Oncol,2003,14(9):1570-1577..
7. BERENSTEIN EG,RTIZ Z.Megestrol acetate for the treatment of anorexiacachexia syndrome[J].Cochrane Database Syst Rev,2005,(2):CD004310..
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11. 韓冬,郭杰.恩丹西酮預(yù)防化療中胃腸道反應(yīng)的臨床觀察[J].河北醫(yī)學(xué),2004,10(10):930-931..
12. 王梅子,許建衡.化療止吐藥物的研究進(jìn)展[J].汕頭大學(xué)醫(yī)學(xué)院學(xué)報,2008,21(2):124..
13. 崔慧娟.醋酸甲地孕酮在晚期腫瘤治療中的應(yīng)用進(jìn)展[J].國外醫(yī)學(xué)腫瘤學(xué)分冊,2001,28(6):473-474..
14. ULUTIN HC,ARPACI F,PAK Y,et al.Megestrol acetate for cachexia and anorexia in advanced non small cell lung cancer:a randomized study comparing two different doses [J].Tumori,2002,88(4):277-280..
15. ROWLAND KMJR,LOPRINZI CL,SHAW EG,et al.Randomized doubleblind placebocontrolled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensivestage smallcell lung cancer:a North Central Cancer Treatment Group study[J].J Clin Oncol,1996,14(1):135-141..
16. 王啟船,王青,孫曉,等.甲地孕酮改善腫瘤患者化療期消化道反應(yīng)療效觀察[J].中國誤診學(xué)雜志,2006,6(23):4572..
17. 何舒.化療止吐藥的研究進(jìn)展[J].國外醫(yī)學(xué)藥學(xué)分冊,2003,30(6):334..
  1. 1.
  2. 2. SCHNELL FM,Chemotherapyinduced nausea and vomiting:the importance of acute antiemetic control[J].Oncologist,2003,8(2):187-198..
  3. 3. GLAUSL A,KNIPPING C,MORANT R,et al.Chemotherapyinduced nausea and vomiting in routine practice:a European perspective[J].Support Care Cancer,2004,12(10):708-715..
  4. 4. HESKTH PJ,KRIS MG,GRUNBERG SM,et al.Proposal for classifying the acute emetogenicity of cancer chemotherapy[J].J Clin Oncol,1997,15(1):103-109..
  5. 5. AAPRO MS,GRUNBERG SM,MANIKHAS GM,et al.A phase Ⅲ,doubleblind,randomized trial of palonosetron compared with ondansetron in preventing chemotherapyinduced nausea and vomiting following highly emetogenic chemotherapy[J].Ann Oncol,2006,17(9):1441-1449..
  6. 6. GRALLA R,LICHINITSER M,SLEEBOOM H,et al.Palonosetron improves prevention of chemotherapyinduced nausea and vomiting following moderately emetogenic chemotherapy:results of a doubleblind randomized phase Ⅲ trial comparing single doses of palonosetron with ondansetron[J].Ann Oncol,2003,14(9):1570-1577..
  7. 7. BERENSTEIN EG,RTIZ Z.Megestrol acetate for the treatment of anorexiacachexia syndrome[J].Cochrane Database Syst Rev,2005,(2):CD004310..
  8. 8. 孫燕.內(nèi)科腫瘤學(xué)[M].北京:人民衛(wèi)生出版社,2003:995..
  9. 9. 南克俊,魏永長,李春麗,等.甲地孕酮改善晚期惡性腫瘤患者生活質(zhì)量[J].第四軍醫(yī)大學(xué)學(xué)報,2002,23(4):350..
  10. 10. 邵紅玲.格拉司瓊與甲氧氯普胺聯(lián)合應(yīng)用預(yù)防化療惡心嘔吐臨床療效觀察[J].實(shí)用醫(yī)技雜志,2007,14(28):3925..
  11. 11. 韓冬,郭杰.恩丹西酮預(yù)防化療中胃腸道反應(yīng)的臨床觀察[J].河北醫(yī)學(xué),2004,10(10):930-931..
  12. 12. 王梅子,許建衡.化療止吐藥物的研究進(jìn)展[J].汕頭大學(xué)醫(yī)學(xué)院學(xué)報,2008,21(2):124..
  13. 13. 崔慧娟.醋酸甲地孕酮在晚期腫瘤治療中的應(yīng)用進(jìn)展[J].國外醫(yī)學(xué)腫瘤學(xué)分冊,2001,28(6):473-474..
  14. 14. ULUTIN HC,ARPACI F,PAK Y,et al.Megestrol acetate for cachexia and anorexia in advanced non small cell lung cancer:a randomized study comparing two different doses [J].Tumori,2002,88(4):277-280..
  15. 15. ROWLAND KMJR,LOPRINZI CL,SHAW EG,et al.Randomized doubleblind placebocontrolled trial of cisplatin and etoposide plus megestrol acetate/placebo in extensivestage smallcell lung cancer:a North Central Cancer Treatment Group study[J].J Clin Oncol,1996,14(1):135-141..
  16. 16. 王啟船,王青,孫曉,等.甲地孕酮改善腫瘤患者化療期消化道反應(yīng)療效觀察[J].中國誤診學(xué)雜志,2006,6(23):4572..
  17. 17. 何舒.化療止吐藥的研究進(jìn)展[J].國外醫(yī)學(xué)藥學(xué)分冊,2003,30(6):334..