李其富 1,2 , 鄭洪波 1 , 蔣毅 1
  • 1． 四川大學(xué)華西醫(yī)院神經(jīng)內(nèi)科,四川成都 610041;2海南醫(yī)學(xué)院附屬醫(yī)院神經(jīng)內(nèi)科,海南?？?570102;

目的:觀察A型肉毒毒素(BTXA)對(duì)面肌痙攣(HFS)患者痙攣程度的改善和生存質(zhì)量的影響。方法: 對(duì)68例HFS患者進(jìn)行局部注射BTXA,治療前及治療后1個(gè)月分別對(duì)患者的痙攣程度進(jìn)行判定和使用世界衛(wèi)生組織生存質(zhì)量評(píng)定量表簡(jiǎn)表(WHOQOL-BREF)評(píng)價(jià)生存質(zhì)量。 結(jié)果: 97.04%的HFS患者在BXTA治療后1個(gè)月痙攣明顯改善緩解,而且患者在WHOQOL-BREF的生理領(lǐng)域、心理領(lǐng)域、社會(huì)關(guān)系領(lǐng)域、總的健康狀況和總的生存質(zhì)量的評(píng)分均明顯高于治療前,差異有統(tǒng)計(jì)學(xué)意義(P lt;0.01)。 結(jié)論: 局部注射BTXA可迅速緩解或消除HFS患者肌肉痙攣,提高患者的生存質(zhì)量。

引用本文： 李其富,鄭洪波,蔣毅. A型肉毒毒素注射對(duì)偏側(cè)面肌痙攣患者生存質(zhì)量的影響. 華西醫(yī)學(xué), 2009, 24(8): 1923-1925. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《華西醫(yī)學(xué)》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

1. SCOTT AB,KENNEDY RA,STUBBS HA.Botulinum A toxic injection as a treatment for blepharospasm[J].Arch Ophthalmol,1985,103:347-350.
2. COHEN DA,SAVINO P,STERN MB,et al.Botulinum injection therapy for blepharospasm:a review and report of 75 patients[J].Chn Neuropharmacol,1986,9:415.
3. 郝元濤,方積乾,李彩霞,等.世界衛(wèi)生組織生存質(zhì)量量表及其中文版介紹及其應(yīng)用說(shuō)明[J].國(guó)外醫(yī)學(xué)社會(huì)醫(yī)學(xué)分冊(cè),1999,16:118-122.
4. JOST WH,KOHL A.Botulinum toxin:evidencebased medicine criteria in blepharospasm and hemifacial spasm[J].Neurol,2001,248:S21-S24.
5. SCHANTZ EJ,JONSOS EA.Properties and use of botulinum toxin and other microtoxins in medicine[J].Mic Rev,1992,56:80.
6. SUPUTTITADA A,PHANTHUMCHINDA K,LOCHARERNKUL C,et al.Hemifacial spasm:results of treatment with low dose botulinum toxin injection[J].J Med Assoc Thail,2004,87:12051211.
7. SCHEIDT CE,SCHULLER B,RAYKI G,et al.Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm[J].Neurology,1996,47:43-45.
8. SCHNIDER P,BIRNER P,MORARU E,et al.Longterm treatment with botulinum toxin:dosage,treatment schedules and costs[J]. Wiener Klinische Wochenschrift,1999,111:59-65.
9. 郝元濤,方積乾.世界衛(wèi)生組織生存質(zhì)量測(cè)定量表中文版介紹及其應(yīng)用說(shuō)明[J].現(xiàn)代康復(fù),2000,4:1127-1129.
10. WHOQOL Group.Development of the World Health Organization WHOQOLBREF quality of life assessment[J].Psychol Med,1998,28:551-558.
11. 鐘萍,蔣毅. A型肉毒毒素治療半側(cè)面肌痙攣的臨床療效評(píng)價(jià)[J].現(xiàn)代生物醫(yī)學(xué)進(jìn)展,2006,6:44-45.
  1. 1. SCOTT AB,KENNEDY RA,STUBBS HA.Botulinum A toxic injection as a treatment for blepharospasm[J].Arch Ophthalmol,1985,103:347-350.
  2. 2. COHEN DA,SAVINO P,STERN MB,et al.Botulinum injection therapy for blepharospasm:a review and report of 75 patients[J].Chn Neuropharmacol,1986,9:415.
  3. 3. 郝元濤,方積乾,李彩霞,等.世界衛(wèi)生組織生存質(zhì)量量表及其中文版介紹及其應(yīng)用說(shuō)明[J].國(guó)外醫(yī)學(xué)社會(huì)醫(yī)學(xué)分冊(cè),1999,16:118-122.
  4. 4. JOST WH,KOHL A.Botulinum toxin:evidencebased medicine criteria in blepharospasm and hemifacial spasm[J].Neurol,2001,248:S21-S24.
  5. 5. SCHANTZ EJ,JONSOS EA.Properties and use of botulinum toxin and other microtoxins in medicine[J].Mic Rev,1992,56:80.
  6. 6. SUPUTTITADA A,PHANTHUMCHINDA K,LOCHARERNKUL C,et al.Hemifacial spasm:results of treatment with low dose botulinum toxin injection[J].J Med Assoc Thail,2004,87:12051211.
  7. 7. SCHEIDT CE,SCHULLER B,RAYKI G,et al.Relative absence of psychopathology in benign essential blepharospasm and hemifacial spasm[J].Neurology,1996,47:43-45.
  8. 8. SCHNIDER P,BIRNER P,MORARU E,et al.Longterm treatment with botulinum toxin:dosage,treatment schedules and costs[J]. Wiener Klinische Wochenschrift,1999,111:59-65.
  9. 9. 郝元濤,方積乾.世界衛(wèi)生組織生存質(zhì)量測(cè)定量表中文版介紹及其應(yīng)用說(shuō)明[J].現(xiàn)代康復(fù),2000,4:1127-1129.
  10. 10. WHOQOL Group.Development of the World Health Organization WHOQOLBREF quality of life assessment[J].Psychol Med,1998,28:551-558.
  11. 11. 鐘萍,蔣毅. A型肉毒毒素治療半側(cè)面肌痙攣的臨床療效評(píng)價(jià)[J].現(xiàn)代生物醫(yī)學(xué)進(jìn)展,2006,6:44-45.