• 1四川大學(xué)華西醫(yī)院急診科, 四川成都 610041;2南通大學(xué)醫(yī)學(xué)院病理教研室;

目的:研究非小細(xì)胞肺癌中PGSK-3β、CEA、C-myc的表達(dá),探討它們與肺癌臨床病理因素的相關(guān)性及在肺癌中三指標(biāo)之間的相關(guān)性。方法:運(yùn)用免疫組化法檢測(cè)90例肺癌PGSK-3β、CEA、C-myc的表達(dá)情況。結(jié)果 肺腺癌PGSK-3β陽(yáng)性率明顯高于鱗癌(P lt;0.05),臨床Ⅲ-Ⅳ期陽(yáng)性率顯著高于Ⅰ-Ⅱ期(P lt;0.05)。周圍型肺癌CEA陽(yáng)性率顯著高于中央型肺癌(P lt;0.01),有淋巴結(jié)轉(zhuǎn)移者陽(yáng)性率顯著高于無(wú)淋巴結(jié)轉(zhuǎn)移者(P lt;0.05)。肺癌中、低分化組C-myc陽(yáng)性率顯著高于高分化組(P lt;0.05);C-myc陽(yáng)性強(qiáng)度表達(dá)呈拋物線狀趨勢(shì),在中分化組顯著高于低分化組和高分化組。肺癌中PGSK-3β與CEA表達(dá)呈正相關(guān)(P lt;0.05)。 結(jié)論:PGSK-3β促進(jìn)肺癌的演進(jìn)過(guò)程,與肺癌的分化、分期相關(guān)。肺癌高表達(dá)CEA時(shí)癌組織異質(zhì)性粘附增加,有利于其浸潤(rùn)與轉(zhuǎn)移。肺癌中C-myc表達(dá)增加是肺癌發(fā)生中的常見分子事件,與癌細(xì)胞分化有關(guān)。肺癌中PGSK-3β與CEA表達(dá)呈正相關(guān)。

引用本文： 王革平,陳莉李信明,張逸,李定明,蔣鵬飛. 非小細(xì)胞肺癌中PGSK-3β、CEA、C-myc表達(dá)與臨床病理因素的相關(guān)性研究. 華西醫(yī)學(xué), 2009, 24(9): 2320-2323. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《華西醫(yī)學(xué)》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

1. JIA J H, AMANAI K, WANG G L, et al. Shaggy/GSK3 antagonizes Hedgehog signaling by regulating Cubitus interruptus[J]. Nature, 2002, 416(6880): 548 -552.
2. SOTOCERRATO V,VINALS F,LAMBERT JR,et al. Prodigiosin induces the proapoptotic gene NAG1 via glycogen synthase kinase3β activity in breast cancer cells[J]. Mol Cancer Ther, 2007, 6 (1): 362-369.
3. LI J, MIZUKAMI Y, ZHANG X, et al.Oncogenic Kras stimulates Wnt singaling in colon cancer through inhibition of GSK3[J]. J Gastroenterology, 2005, 128 (7):1907-1918.
4. LEI SA, DUBEYKOVSKIY A, CHAKLADAR L, et al. The murine gastrin promoter is synergistically activated by transforming growth factorβ/ SMAD and Wnt signaling pathways[J]. J Biol Chem, 2004, 279 (41): 42492-42502.
5. DING VW, CHEN RH,MCCORMICK FJ. Differential regulation of glycogen synthase kinase3βby insulin and wnt signaling[J]. Biol Chem, 2000, 275 (42): 32475-32481.
6. LIANG J, SLINGERLAND J M. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycleprogression[J]. Cell Cycle, 2003, 2 (4):339-345.
7. ALT J R, CLEVELAND J L, HANNINK M, et al. Phosphorylation dependent regulation of cyclinD1 nuclear export and cyclinD1dependent cellular transformation[J]. Genes Dev, 2000,14 (24):3102-3114.
8. BAN KC, SINGH H, KRISHNAN R, et al. GSK3 β phosphorylation and alteration of βcatenin in hepatocellularcarcinoma[J]. Cancer Lett, 2003, 199 (2): 201-208.
9. GOTO H, KAWANO K, KOBAYASHI I, et al. Expression of cyclin D1 and GSK3β and their predictivevalue of prognosis in squamous cell carcinomas of the tongue[J].Oral Oncol, 2002, 38 (6): 549-556.
10. HA N C, TONOZUKA T, STAMOS J L, CHOI HJ, WEIS W I. Mechanism of phosphorylationdependent binding of APC to βcatenin and its role in βcatenin degradation[J]. Mol Cell, 2004, 15 (4): 511-521.
11. 王志新, 高明發(fā). 非小細(xì)胞肺癌癌胚抗原表達(dá)的臨床意義[J]. 第三軍醫(yī)大學(xué)學(xué)報(bào), 2001, 23 (1): 102-104.
12. LU LX, JIANG HC, ZHU AL. Gene expression profiles in liver cancer and normal liver tissues[J]. World J Gastroenterol, 2000, 6 (suppl3): 85.
13. WANG Q, LIN ZY, FENG XL. Alterations in metastatic properties of hepat ocellular carcinoma cell following oncogene transfection[J].World J Gastroentero L, 2001, 7 (3): 335-339.
14. LI J, MIZUKAMI Y, ZHANG X, et al.Oncogenic Kras stimulates Wnt singaling in colon cancer through inhibition of GSK3β[J]. J Gastroenterology, 2005, 128 (7): 1907-1918.
15. XU AG, LI SG, LIU J H, et al.Function of apoptosis and expression of he proteins Bcl2, p53 and Cmyc in the development of gastric cancer[J]. World J Gastroenterol, 2001, 7 (3): 403406.
  1. 1. JIA J H, AMANAI K, WANG G L, et al. Shaggy/GSK3 antagonizes Hedgehog signaling by regulating Cubitus interruptus[J]. Nature, 2002, 416(6880): 548 -552.
  2. 2. SOTOCERRATO V,VINALS F,LAMBERT JR,et al. Prodigiosin induces the proapoptotic gene NAG1 via glycogen synthase kinase3β activity in breast cancer cells[J]. Mol Cancer Ther, 2007, 6 (1): 362-369.
  3. 3. LI J, MIZUKAMI Y, ZHANG X, et al.Oncogenic Kras stimulates Wnt singaling in colon cancer through inhibition of GSK3[J]. J Gastroenterology, 2005, 128 (7):1907-1918.
  4. 4. LEI SA, DUBEYKOVSKIY A, CHAKLADAR L, et al. The murine gastrin promoter is synergistically activated by transforming growth factorβ/ SMAD and Wnt signaling pathways[J]. J Biol Chem, 2004, 279 (41): 42492-42502.
  5. 5. DING VW, CHEN RH,MCCORMICK FJ. Differential regulation of glycogen synthase kinase3βby insulin and wnt signaling[J]. Biol Chem, 2000, 275 (42): 32475-32481.
  6. 6. LIANG J, SLINGERLAND J M. Multiple roles of the PI3K/PKB (Akt) pathway in cell cycleprogression[J]. Cell Cycle, 2003, 2 (4):339-345.
  7. 7. ALT J R, CLEVELAND J L, HANNINK M, et al. Phosphorylation dependent regulation of cyclinD1 nuclear export and cyclinD1dependent cellular transformation[J]. Genes Dev, 2000,14 (24):3102-3114.
  8. 8. BAN KC, SINGH H, KRISHNAN R, et al. GSK3 β phosphorylation and alteration of βcatenin in hepatocellularcarcinoma[J]. Cancer Lett, 2003, 199 (2): 201-208.
  9. 9. GOTO H, KAWANO K, KOBAYASHI I, et al. Expression of cyclin D1 and GSK3β and their predictivevalue of prognosis in squamous cell carcinomas of the tongue[J].Oral Oncol, 2002, 38 (6): 549-556.
  10. 10. HA N C, TONOZUKA T, STAMOS J L, CHOI HJ, WEIS W I. Mechanism of phosphorylationdependent binding of APC to βcatenin and its role in βcatenin degradation[J]. Mol Cell, 2004, 15 (4): 511-521.
  11. 11. 王志新, 高明發(fā). 非小細(xì)胞肺癌癌胚抗原表達(dá)的臨床意義[J]. 第三軍醫(yī)大學(xué)學(xué)報(bào), 2001, 23 (1): 102-104.
  12. 12. LU LX, JIANG HC, ZHU AL. Gene expression profiles in liver cancer and normal liver tissues[J]. World J Gastroenterol, 2000, 6 (suppl3): 85.
  13. 13. WANG Q, LIN ZY, FENG XL. Alterations in metastatic properties of hepat ocellular carcinoma cell following oncogene transfection[J].World J Gastroentero L, 2001, 7 (3): 335-339.
  14. 14. LI J, MIZUKAMI Y, ZHANG X, et al.Oncogenic Kras stimulates Wnt singaling in colon cancer through inhibition of GSK3β[J]. J Gastroenterology, 2005, 128 (7): 1907-1918.
  15. 15. XU AG, LI SG, LIU J H, et al.Function of apoptosis and expression of he proteins Bcl2, p53 and Cmyc in the development of gastric cancer[J]. World J Gastroenterol, 2001, 7 (3): 403406.