• 1川北醫(yī)學(xué)院附屬醫(yī)院急診科,四川南充 637000;2四川大學(xué)華西醫(yī)院急診科,四川成都 610041;

目的:觀察百草枯中毒大鼠血漿和肺組織勻漿中的內(nèi)皮素-1的動(dòng)態(tài)變化,探討大鼠PQ中毒肺損傷的可能機(jī)制。方法:將雄性Wistar大鼠隨機(jī)分成百草枯中毒組和生理鹽水對(duì)照組,分別給予16mg/kg百草枯或等體積生理鹽水腹腔內(nèi)注射,并在給藥后6、12、24和72 h處死大鼠,觀察其一般表現(xiàn)、肺的病理變化。測(cè)定肺系數(shù)、肺組織勻漿和血漿中內(nèi)皮素-1的含量。結(jié)果: 百草枯中毒后大鼠出現(xiàn)呼吸困難,活動(dòng)能力下降,肺系數(shù)增加,并隨時(shí)間變化,光鏡下表現(xiàn)為肺出血、水腫等不同程度的肺損傷改變。血漿和組織勻漿中內(nèi)皮素-1在中毒后與對(duì)照組大鼠比較明顯升高,并隨時(shí)間變化(P lt;0.01)。結(jié)論:在百草枯中毒肺損傷中,內(nèi)皮素-1可能發(fā)揮了重要作用。

引用本文： 劉世平,何慶. 內(nèi)皮素-1在大鼠百草枯中毒中的機(jī)制研究. 華西醫(yī)學(xué), 2009, 24(9): 2338-2340. doi: 復(fù)制

版權(quán)信息： ?四川大學(xué)華西醫(yī)院華西期刊社《華西醫(yī)學(xué)》版權(quán)所有，未經(jīng)授權(quán)不得轉(zhuǎn)載、改編

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