目的 探討肝動脈化療栓塞(TACE)對原發(fā)性肝癌(簡稱肝癌)術后患者生存及腫瘤復發(fā)的影響,為肝癌患者的臨床診治提供參考依據(jù)。
方法 選取我院2007年2月至2011年2月期間收治的220例原發(fā)性肝癌患者,依治療方式分為TACE組與對照組,各110例,TACE組患者術后行TACE治療,對照組患者術后未行TACE治療,分析比較2組患者術后生存率與腫瘤復發(fā)率。
結果 TACE組患者1、2、3年生存率分別為83.64%、56.36%和42.73%,對照組1、2、3年生存率分別為65.45%、40.91%和21.82%,TACE組患者的1、2、3年生存率均分別明顯高于對照組(P<0.05)。TACE組患者1、2、3年腫瘤復發(fā)率分別為20.91%、54.55%和67.27%,對照組患者1、2、3年腫瘤復發(fā)率分別為38.18%、57.27%和70.91%,第1年腫瘤復發(fā)率TACE組明顯低于對照組(P<0.05),但2、3年腫瘤復發(fā)率2組間比較,差異均無統(tǒng)計學意義(P>0.05)。
結論 肝癌患者術后行TACE可提高患者長期生存率,但并不能降低患者長期腫瘤復發(fā)率。
引用本文: 王翔翔,余華,熊杰,劉明忠,孫建明,趙宇. 肝動脈化療栓塞對原發(fā)性肝癌患者術后生存及復發(fā)的影響. 中國普外基礎與臨床雜志, 2012, 19(11): 1204-1207. doi: 復制
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5. | 鐘妮, 潘桂華, 張華, 等. 超選擇性肝動脈灌注化療栓塞術治療中晚期肝癌經(jīng)驗總結(附67例報告)[J]. 當代醫(yī)學, 2010, 16(31):71-72. |
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10. | 肖開銀, 彭民浩. 原發(fā)性肝癌合并門靜脈癌栓的治療進展[J]. 中國普外基礎與臨床雜志, 2012, 19(3):259-265. |
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14. | 錢智玲, 崔世昌, 王海燕. 雙介入法治療原發(fā)性肝癌療效的臨床研究[J]. 中國普外基礎與臨床雜志, 2008, 15(9):686-689. |
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25. | 文潔, 朱德增. 中晚期原發(fā)性肝癌患者的危險因素分析[J]. 中國現(xiàn)代醫(yī)學雜志, 2011, 21(7):841-845. |
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27. | 吳育連, 蘇昆侖, 董鑫, 等. 肝癌切除術后早/晚期復發(fā)的危險因素與治療[J]. 中華肝膽外科雜志, 2006, 12(6):370-373. |
28. | , 18(4):450-455. |
- 1. 張慶, 吳力群, 張順, 等. 原發(fā)性肝癌術后行肝動脈化療栓塞治療對患者生存及腫瘤復發(fā)的影響[J]. 中國現(xiàn)代普通外科進展, 2011, 14(2):126-129.
- 2. 張坤, 江藝, 張紹庚, 等. 肝動脈化療栓塞對原發(fā)性肝癌患者術后生存及腫瘤復發(fā)的影響[J]. 中國普通外科雜志, 2007, 16(3):206-208.
- 3. 羅懿忠, 區(qū)金銳. TNM分期評價肝癌術后TACE及預后的價值[J]. 廣東醫(yī)學, 2009, 30(11):1701-1703.
- 4. Poon RT, Fan ST, Ng IO, et al. Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma[J]. Cancer, 2000, 89(3):500-507.
- 5. 鐘妮, 潘桂華, 張華, 等. 超選擇性肝動脈灌注化療栓塞術治療中晚期肝癌經(jīng)驗總結(附67例報告)[J]. 當代醫(yī)學, 2010, 16(31):71-72.
- 6. Paterson DL, Ko WC, Von Gottberg A, et al. Internationalprospective study of Klebsiella pneumoniae bacteremia:implications of extended-spectrum beta-lactamase production in nosocomialinfections[J]. Ann Intern Med, 2004, 140(1):26-32.
- 7. Bruix J, Hessheimer AJ, Forner A, et al. New aspects of diagnosis and therapy of hepatocellular carcinoma[J]. Oncogene, 2006, 25(27):3848-3856.
- 8. Zhong JH, Li le Q, Wu LC. Lamivudine with or withoutadefovir dipivoxil for postoperative hepatocellular carcinoma[J]. Cochrane Database Syst Rev, 2011, (12):CD008713.
- 9. Lu X, Zhao H, Yang H, et al. A prospective clinical study on early recurrence of hepatocellular carcinoma after hepatectomy[J]. J Surg Oncol, 2009, 100(6):488-493.
- 10. 肖開銀, 彭民浩. 原發(fā)性肝癌合并門靜脈癌栓的治療進展[J]. 中國普外基礎與臨床雜志, 2012, 19(3):259-265.
- 11. Izumi R, Shimizu K, Iyobe T, et al. Postoperative adjuvanthepatic arterial infusion of Lipiodol containing anticancer drugs in patients with hepatocellular carcinoma[J]. Hepatology, 1994, 20(2):295-301.
- 12. Kwok PC, Lam TW, Lam PW, et al. Randomized controlled trial to compare the dose of adjuvant chemotherapy after curative resection of hepatocellular carcinoma[J]. J Gastroenterol Hepatol,.
- 13. Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma:Chemoembolizationimproves survival[J]. Hepatology, 2003, 37(2):429-442.
- 14. 錢智玲, 崔世昌, 王海燕. 雙介入法治療原發(fā)性肝癌療效的臨床研究[J]. 中國普外基礎與臨床雜志, 2008, 15(9):686-689.
- 15. 何平, 李金龍, 陳勇, 等. 中晚期肝癌聯(lián)合介入治療175例報道[J]. 中國普外基礎與臨床雜志, 2010, 17(6):615-617.
- 16. 陳哲宇, 盧武勝, 嚴律南. 肝癌合并門靜脈癌栓術后兩種治療方式比較[J]. 中國普外基礎與臨床雜志, 2012, 19(3):252-255.
- 17. Meng MB, Cui YL, Lu Y, et al. Transcatheter arterial chemoembolization in combination with radiotherapy for unresectable hepatocellular carcinoma:a systematic review and meta-analysis[J]. Radiother Oncol, 2009, 92(2):184-194.
- 18. Peng BG, He Q, Li JP, et al. Adjuvant transcatheter arterial chemoembolization improves efficacy of hepatectomy for patients with hepatocellular carcinoma and portal vein tumor thrombus[J]. Am J Surg, 2009, 198(3):313-318.
- 19. 余正平, 徐正鏗, 周為中, 等. 原發(fā)性肝癌根治術后輔助肝動脈栓塞化療預防肝內(nèi)復發(fā)的療效[J]. 實用醫(yī)學雜志, 2009, 25(11):1819-1821.
- 20. Liu Y, Yang R. Preoperative combined with postoperative chemoembolization can improve survival in patients with hepatocellular carcinoma:a single-center study[J]. J Vasc Interv Radiol, 2009, 20(4):472-483.
- 21. Shin SW. The current practice of transarterial chemoembolizationfor the treatment of hepatocellular carcinoma[J]. Korean JRadiol, 2009, 10(5):425-434.
- 22. Tung-Ping Poon R, Fan ST, Wong J. Risk factors, prevention, and management of postoperative recurrence after resection of hepatocellular carcinoma[J]. Ann Surg, 2000, 232(1):10-24.
- 23. 陳曉泓, 張博恒, 殷欣, 等. 肝細胞癌根治術后行輔助性肝動脈化療栓塞對近期復發(fā)的作用[J]. 中華醫(yī)學雜志, 2010, 90(12):826-829.
- 24. Lau WY, Yu SC, Lai EC, et al. Transarterial chemoembolization for hepatocellular carcinoma[J]. J Am Coll Surg, 2006, 202(1):155-168.
- 25. 文潔, 朱德增. 中晚期原發(fā)性肝癌患者的危險因素分析[J]. 中國現(xiàn)代醫(yī)學雜志, 2011, 21(7):841-845.
- 26. Kubo S, Hirohashi K, Yamazaki O, et al. Effect of the presence of hepatitis B e antigen on prognosis after liver resection for hepatocellular carcinoma in patients with chronic hepatitis B[J]. World J Surg, 2002, 26(5):555-560.
- 27. 吳育連, 蘇昆侖, 董鑫, 等. 肝癌切除術后早/晚期復發(fā)的危險因素與治療[J]. 中華肝膽外科雜志, 2006, 12(6):370-373.
- 28. , 18(4):450-455.