• 1.蘭州軍區(qū)烏魯木齊總醫(yī)院普外科(烏魯木齊830000);;
  • 2.蘭州軍區(qū)烏魯木齊總醫(yī)院病理科((烏魯木齊830000);;
  • 3.第四軍醫(yī)大學唐都醫(yī)院(西安710038);

目的  探討p16和p53蛋白在膽囊癌發(fā)生、發(fā)展中的作用及其相關性。
方法  應用免疫組化法對40例膽囊癌組織中p16和p53蛋白的表達情況進行檢測。
結果  p16和p53蛋白的表達與膽囊癌的組織學分化，淋巴結轉移以及預后相關； p16蛋白的表達還與臨床分期有關。結論 p16蛋白的失表達是發(fā)生在膽囊癌發(fā)展的晚期階段，認為p16和p53蛋白的表達有助于原發(fā)性膽囊癌的分化及其預后的判斷。

引用本文： 張東,馮德元,王平,鄒賽英,何澤生. 抑癌基因p16和p53在原發(fā)性膽囊癌中的表達及其相關性的初步研究. 中國普外基礎與臨床雜志, 2000, 7(2): 85-86. doi: 復制

版權信息： ?四川大學華西醫(yī)院華西期刊社《中國普外基礎與臨床雜志》版權所有，未經(jīng)授權不得轉載、改編

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  2. 2. Walker DG, Duan W, Popovic EA, et al. Homozygous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas 〔Ｊ〕. Cancer Res, 1995; 55(1)∶20.
  3. 3. Fujimoto K, Yamada Y, Okajima E, et al. Frequent association of p53 gene mutation in invasive bladder cancer 〔Ｊ〕. Cancer Res, 1992; 52(6)∶1393.
  4. 4. Rigaudy P, Echhart W. Nucleotide sequence of a CDNA encoding the monkey cellular phosphoprotein p53 〔Ｊ〕. Nucleic Acids Res, 1989; 17(20)∶8375.