目的:觀察比較胃鏡下硬化劑注射聯(lián)合藥物治療和單純硬化劑注射治療、藥物治療食管靜脈曲張出血的療效。方法:95例肝硬化并食管靜脈曲張出血患者,分成三組。32例患者給予硬化劑注射聯(lián)合藥物治療,31例患者給予硬化劑治療,32例患者給予藥物治療。觀察三組患者急診止血率,近期出血率、遠(yuǎn)期再出血率、曲張靜脈消失率、曲張靜脈復(fù)發(fā)率。 結(jié)果: 聯(lián)合組、硬化劑組、藥物組急診止血率分別為93.8%.90.3%、68.8%;聯(lián)合組、硬化劑組、藥物組近期出血率分別為6.3%、9.7%、46.9%;聯(lián)合組、硬化劑組、藥物組曲張靜脈消失率分別為90.6%、83.9%、1.9%;聯(lián)合組、硬化組與藥物組急診止血率、近期出血率、曲張靜脈消失率有顯著差異。聯(lián)合組、硬化劑組、藥物組遠(yuǎn)期出血率分別為9.4%、59.4%、31.3%; 聯(lián)合組、硬化劑組、藥物組曲張靜脈復(fù)發(fā)率分別為18.8%、45.2%、87.5%;聯(lián)合組與硬化組、藥物組遠(yuǎn)期出血率、曲張靜脈復(fù)發(fā)率有顯著差異。結(jié)論:胃鏡下硬化劑注射聯(lián)合藥物治療食管靜脈曲張出血可顯著提高療效。
摘要:目的: 探討PCNA,VEGF在胃癌組織中的表達(dá)關(guān)系及其意義。 方法 :免疫組織化學(xué)法檢測(cè)正常胃和胃癌組織中PCNA和VEGF的表達(dá),并分析其與胃癌臨床病理特征的相關(guān)性。 結(jié)果 :胃癌組織中PCNA、VEGF的陽(yáng)性表達(dá)率分別為850%、683%,二者在正常胃組織中均為隱性表達(dá)。PCNA的表達(dá)與腫瘤分期、淋巴結(jié)轉(zhuǎn)移有關(guān)(〖WTBX〗P lt;005),而與年齡、性別、腫瘤大小、組織分化程度無(wú)關(guān)(〖WTBX〗P gt;005);PCNA的表達(dá)與腫瘤分期、淋巴結(jié)轉(zhuǎn)移有關(guān)(〖WTBX〗P lt;005),而與年齡、性別、腫瘤大小、組織分化程度無(wú)關(guān)(〖WTBX〗P gt;005)。PCNA和VEGF在胃癌中的表達(dá)呈正相關(guān)。 結(jié)論 :PCNA和VEGF在胃癌組織中的高表達(dá)促進(jìn)了胃癌的發(fā)生發(fā)展。Abstract: Objective: To study the significance and relationship of expression of proliferating cell nuclear antigen(PCNA) and vascular endothelial growth factor (VEGF) in gastric cancer. Methods : The expression of VEGF and PCNA in normal gastric tissues and gastric cancer tissues were detected by immunohistochemistry (SP),and clinic pathological correlation with gastric cancer was analyzed. Results : The positive exression rates of PCNA and VEGF in gastric cancer were 850%、683%, respectively, while negative expression was shown in normal gastric tissues. It was found that the expressions of PCNA and VEGF were both in significant relation to TNM stages and lymph node metastasis (P lt;005), but in no relation to age, gender, diameter of tumor and tumor cell differentiation (P gt;005). The expressions of PCNA and VEGF were positively correlated with each other. Conclusion : It was indicated that the highlevel expressions of PCNA and VEGF might corporately accelerate the progression of gastric cancer.