精神障礙與糖尿病之間相互作用機制復雜，涉及遺傳、內分泌代謝、炎癥反應、氧化應激等多個方面，導致精神障礙合并糖尿病患者治療難度大。此類患者現多采用藥物及非藥物干預方式來緩解精神障礙癥狀和改善血糖水平，但目前對精神障礙與糖尿病的作用機制還需要系統(tǒng)性的概括及切實可行的干預手段。該文從糖尿病發(fā)病機制談起，詳細敘述了精神分裂癥、雙相情感障礙及抑郁癥與糖尿病的交互作用機制，總結了精神障礙合并糖尿病患者的干預措施，旨在為從事相關工作的醫(yī)務人員提供參考。
摘要:目的: 觀察免費治療社區(qū)精神分裂癥患者的療效。 方法 :納入貧困家庭精神分裂癥患者140例,隨機分為免費服藥組和對照組,每組70例。隨訪1年,采用精神分裂癥陽性與陰性癥狀量表(PANSS)\社會功能缺陷量表(SDSS)等評估。 結果 :對實驗組與對照組的基線、6個月后及1年后隨訪的PANSS總分、各因子分、SDSS總分分別進行比較,結果顯示基線、6月后均無統(tǒng)計學差異;1年后SDSS總分、PANSS總分、陽性因子分、一般病理因子、思維障礙、偏執(zhí)因子分差異有顯著性;免費治療組1年后各指標與入組前相比分值降低(P＜001)。 結論 :精神分裂癥患者免費服藥后精神癥狀緩解明顯,同時其社會功能缺陷也得到改善。Abstract: Objective: To observe the effect of the free treatment on schizophrenics from community. Methods : Totally 140 subjects from poor family were divided into the free treated group and the control group at random. They were followed up for 1 year. The treatment effects were evaluated by PANSS and SDSS. Results : There were no significant difference in all examinations at baseline and after 6 months; at the following end point, significant difference existed in the score of SDSS, the total scores of the PANSS, the positive factor, the general pathology factor, the thinking factor and the paranoid ideation factor between two groups. There was decrease in the scores for all examinations in the free treated group. Conclusion : The symptoms of schizophrenics by free treatment relieve significantly, and the social function improves.