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PTTG、CMYC基因過表達與非小細胞肺癌發(fā)生、發(fā)展的關(guān)系及其臨床意義

摘要:目的:探討PTTG的表達在非小細胞肺癌發(fā)生、發(fā)展中的作用及其與CMYC蛋白表達的關(guān)系。方法:應(yīng)用免疫組化SP法檢測PTTG、CMYC二種蛋白在44例非小細胞肺癌、20例肺良性病變組織和12例正常支氣管粘膜上皮組織中的表達。結(jié)果:PTTG和CMYC蛋白在非小細胞肺癌組織中的表達明顯高于肺良性病變組及癌旁組織,在TNM分期、淋巴結(jié)轉(zhuǎn)移組間差別有統(tǒng)計學(xué)意義。非小細胞肺癌組織中PTTG與CMYC表達呈顯著正相關(guān)。結(jié)論:提示PTTG和CMYC可能參與了非小細胞肺癌的發(fā)生和發(fā)展,可作為反映其生物學(xué)行為的指標(biāo)。Abstract: Objective: To investigate the expression of PTTG and its relationship with expressions of CMYC protein in human nonsmall cell lung cancer (NSCLC).Methods: Immunohistochemical methods were applied to detect the expression of PTTG,CMYCproteins in 44 surgical specimens from NSCLC patients,20 pneumonic benign lesion and 19 normal bronchial epithelium. Results:There were high erexpressions of PTTG,CMYC in NSCLC tissues than inadjacent tissues and benign lesions.There were statistical relationships between their expressions and TNM stage,lymphnode metastasis.The expression of PTTG was positively correlated with CMYC. Conclusion: Overexpression of PTTG,CMYC may be related to human NSCLC,PTTG and CMYC play a cooperative role inthe process of NSCLC,all of them may be used as important indices for biologic behavior of NSCLC.