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血清前白蛋白、膽堿脂酶、總膽汁酸在肝硬化中的檢測(cè)價(jià)值

摘要:目的: 探討血清前白蛋白(prealbumin,PAB)、膽堿脂酶(cholinesterase,ChE)、總膽汁酸(total bile acid,TBA)在肝硬化中的檢測(cè)價(jià)值。 方法 :測(cè)定105例肝硬化患者和30例健康人的前白蛋白、膽堿脂酶、總膽汁酸活性及肝功能生化指標(biāo),并按ChildPugh分級(jí)進(jìn)行比較。 結(jié)果 :肝硬化組前白蛋白含量、膽堿脂酶活性均較對(duì)照組顯著降低;按ChildPugh分級(jí)比較,肝硬化組前白蛋白含量在Child A級(jí)與對(duì)照組、B級(jí)與A級(jí)之間、在C級(jí)與B級(jí)之間差異有顯著性(Plt;001);膽堿脂酶活性在Child A級(jí)與對(duì)照組、B級(jí)與A級(jí)、C級(jí)與B級(jí)之間差異有顯著性(Plt;001)?？偰懼嵩贑hild B級(jí)與A級(jí),C級(jí)與B級(jí)間有顯著差異性,在A級(jí)與對(duì)照組間差異無顯著性。 結(jié)論 :血清前白蛋白、膽堿脂酶在肝硬化早期評(píng)估中有很重要的價(jià)值,而總膽汁酸在肝硬化預(yù)后的判定中有重要價(jià)值。 Abstract: Objective: To evaluate the role of prealbumin (PAB), cholinesterase (ChE), and total bile acid (TBA) in evaluating liver reserve function in patients with liver cirrhosis. Methods : One hundred and five serum samples from patients with liver cirrhosis were detected in PAB, ChE, TBA and other biochemical markers. All patients were classified in accordance with ChildPugh scale. Results : For PAB, the differences among ChildPugh A, B, C and healthy group were statistically significant (t=1254, 1887, 2316) (Plt;001). For ChE, the differences among ChildPugh A, B, C and healthy group were statistically significant (t=1288, 0856, 1002) (Plt;001). For TBA, the differences among ChildPugh C group, B group and A group were statistically significant (t=0526, 1081)(Plt;001), the difference among ChildPugh A group and healthy group was not statistically significant (t=5615) (Pgt;005). Conclusion : PAB and ChE reflect liver reserve function earlier in patients with liver cirrhosis. The role of TBA is important in reflecting prognosis in patients with liver cirrhosis.